Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential
Identifieur interne : 004603 ( Main/Exploration ); précédent : 004602; suivant : 004604Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential
Auteurs : Wei Lu [République populaire de Chine] ; Xiao-Dong Wu [République populaire de Chine] ; Mu De Shi [République populaire de Chine] ; Rui Fu Yang ; You Yu He ; Chao Bian [République populaire de Chine] ; Tie Liu Shi ; Sheng Yang ; Xue-Liang Zhu [République populaire de Chine] ; Wei-Hong Jiang ; Yi Xue Li ; Lin-Chen Yan [République populaire de Chine] ; Yong Yong Ji [République populaire de Chine] ; Ying Lin [République populaire de Chine] ; Guo-Mei Lin [République populaire de Chine] ; Lin Tian [République populaire de Chine] ; Jin Wang ; Hong Xia Wang ; You Hua Xie [République populaire de Chine] ; Gang Pei [République populaire de Chine] ; Jia Rui Wu [République populaire de Chine] ; Bing Sun [République populaire de Chine]Source :
- Febs Letters [ 0014-5793 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- usage thérapeutique : Peptides.
- Biologie informatique, Données de séquences moléculaires, Humains, Peptides, Protéines virales, Séquence d'acides aminés, Technique de Western, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Peptides, Viral Proteins.
- chemical , therapeutic use : Peptides.
- chemistry : SARS Virus.
- Amino Acid Sequence, Blotting, Western, Computational Biology, Humans, Molecular Sequence Data.
Abstract
The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is an important viral structural protein. Based on bioinformatics analysis, 10 antigenic peptides derived from the S protein sequence were selected and synthesized. The antigenicity and immunoreactivity of all the peptides were tested in vivo and in vitro. Four peptides (P6, P8, P9 and P10) which contain B cell epitopes of the S protein were identified, and P8 peptide was confirmed in vivo to have a potential in serological diagnosis. By using a syncytia formation model, we tested the neutralization ability of all 10 peptides and their corresponding antibodies. It is interesting to find that P8 and P9 peptides inhibited syncytia formation, suggesting that the P8 and P9 spanning regions may provide a good target for anti-SARS-CoV drug design. Our data suggest that we have identified peptides derived from the S protein of SARS-CoV, which are useful for SARS treatment and diagnosis.
Url:
DOI: 10.1016/j.febslet.2005.02.070
PubMed: 15811330
PubMed Central: 7094314
Affiliations:
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of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Xiao Dong" sort="Wu, Xiao Dong" uniqKey="Wu X" first="Xiao-Dong" last="Wu">Xiao-Dong Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Mu De" sort="Shi, Mu De" uniqKey="Shi M" first="Mu De" last="Shi">Mu De Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Rui Fu" sort="Yang, Rui Fu" uniqKey="Yang R" first="Rui Fu" last="Yang">Rui Fu Yang</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="He, You Yu" sort="He, You Yu" uniqKey="He Y" first="You Yu" last="He">You Yu He</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Bian, Chao" sort="Bian, Chao" uniqKey="Bian C" first="Chao" last="Bian">Chao Bian</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Tie Liu" sort="Shi, Tie Liu" uniqKey="Shi T" first="Tie Liu" last="Shi">Tie Liu Shi</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Yang, Sheng" sort="Yang, Sheng" uniqKey="Yang S" first="Sheng" last="Yang">Sheng Yang</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Zhu, Xue Liang" sort="Zhu, Xue Liang" uniqKey="Zhu X" first="Xue-Liang" last="Zhu">Xue-Liang Zhu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Wei Hong" sort="Jiang, Wei Hong" uniqKey="Jiang W" first="Wei-Hong" last="Jiang">Wei-Hong Jiang</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Li, Yi Xue" sort="Li, Yi Xue" uniqKey="Li Y" first="Yi Xue" last="Li">Yi Xue Li</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Yan, Lin Chen" sort="Yan, Lin Chen" uniqKey="Yan L" first="Lin-Chen" last="Yan">Lin-Chen Yan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Ji, Yong Yong" sort="Ji, Yong Yong" uniqKey="Ji Y" first="Yong Yong" last="Ji">Yong Yong Ji</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Guo Mei" sort="Lin, Guo Mei" uniqKey="Lin G" first="Guo-Mei" last="Lin">Guo-Mei Lin</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Tian, Lin" sort="Tian, Lin" uniqKey="Tian L" first="Lin" last="Tian">Lin Tian</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Jin" sort="Wang, Jin" uniqKey="Wang J" first="Jin" last="Wang">Jin Wang</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Wang, Hong Xia" sort="Wang, Hong Xia" uniqKey="Wang H" first="Hong Xia" last="Wang">Hong Xia Wang</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Xie, You Hua" sort="Xie, You Hua" uniqKey="Xie Y" first="You Hua" last="Xie">You Hua Xie</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Pei, Gang" sort="Pei, Gang" uniqKey="Pei G" first="Gang" last="Pei">Gang Pei</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jia Rui" sort="Wu, Jia Rui" uniqKey="Wu J" first="Jia Rui" last="Wu">Jia Rui Wu</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Laboratory of Molecular Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">E-institutes of Shanghai Universities Immunology Division, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>E-institutes of Shanghai Universities Immunology Division</wicri:regionArea></affiliation></author></analytic><series><title level="j">Febs Letters</title><idno type="ISSN">0014-5793</idno><idno type="eISSN">1873-3468</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Blotting, Western</term><term>Computational Biology</term><term>Humans</term><term>Molecular Sequence Data</term><term>Peptides (chemistry)</term><term>Peptides (therapeutic use)</term><term>SARS Virus (chemistry)</term><term>Viral Proteins (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Biologie informatique</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Peptides ()</term><term>Peptides (usage thérapeutique)</term><term>Protéines virales ()</term><term>Séquence d'acides aminés</term><term>Technique de Western</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Peptides</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Peptides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Blotting, Western</term><term>Computational Biology</term><term>Humans</term><term>Molecular Sequence Data</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Biologie informatique</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Peptides</term><term>Protéines virales</term><term>Séquence d'acides aminés</term><term>Technique de Western</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The spike (S) protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is an important viral structural protein. Based on bioinformatics analysis, 10 antigenic peptides derived from the S protein sequence were selected and synthesized. The antigenicity and immunoreactivity of all the peptides were tested in vivo and in vitro. Four peptides (P6, P8, P9 and P10) which contain B cell epitopes of the S protein were identified, and P8 peptide was confirmed in vivo to have a potential in serological diagnosis. By using a syncytia formation model, we tested the neutralization ability of all 10 peptides and their corresponding antibodies. It is interesting to find that P8 and P9 peptides inhibited syncytia formation, suggesting that the P8 and P9 spanning regions may provide a good target for anti-SARS-CoV drug design. Our data suggest that we have identified peptides derived from the S protein of SARS-CoV, which are useful for SARS treatment and diagnosis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Gunther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, T G" uniqKey="Ksiazek T">T.G. Ksiazek</name></author><author><name sortKey="Goldsmith, C S" uniqKey="Goldsmith C">C.S. Goldsmith</name></author><author><name sortKey="Zaki, S R" uniqKey="Zaki S">S.R. Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T. Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S. Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S. 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Martina</name></author><author><name sortKey="Van Der Zee, Ruurd" uniqKey="Van Der Zee R">Ruurd van der Zee</name></author><author><name sortKey="Lepault, Jean" uniqKey="Lepault J">Jean Lepault</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, T Y" uniqKey="Ho T">T.Y. Ho</name></author><author><name sortKey="Wu, S L" uniqKey="Wu S">S.L. Wu</name></author><author><name sortKey="Cheng, S E" uniqKey="Cheng S">S.E. Cheng</name></author><author><name sortKey="Wei, Y C" uniqKey="Wei Y">Y.C. Wei</name></author><author><name sortKey="Huang, S P" uniqKey="Huang S">S.P. Huang</name></author><author><name sortKey="Hsiang, C Y" uniqKey="Hsiang C">C.Y. Hsiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stavrinides, J" uniqKey="Stavrinides J">J. Stavrinides</name></author><author><name sortKey="Guttman, D S" uniqKey="Guttman D">D.S. 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Choe</name></author><author><name sortKey="Farzan, M A" uniqKey="Farzan M">M.A. Farzan</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="He, You Yu" sort="He, You Yu" uniqKey="He Y" first="You Yu" last="He">You Yu He</name><name sortKey="Jiang, Wei Hong" sort="Jiang, Wei Hong" uniqKey="Jiang W" first="Wei-Hong" last="Jiang">Wei-Hong Jiang</name><name sortKey="Li, Yi Xue" sort="Li, Yi Xue" uniqKey="Li Y" first="Yi Xue" last="Li">Yi Xue Li</name><name sortKey="Shi, Tie Liu" sort="Shi, Tie Liu" uniqKey="Shi T" first="Tie Liu" last="Shi">Tie Liu Shi</name><name sortKey="Wang, Hong Xia" sort="Wang, Hong Xia" uniqKey="Wang H" first="Hong Xia" last="Wang">Hong Xia Wang</name><name sortKey="Wang, Jin" sort="Wang, Jin" uniqKey="Wang J" first="Jin" last="Wang">Jin Wang</name><name sortKey="Yang, Rui Fu" sort="Yang, Rui Fu" uniqKey="Yang R" first="Rui Fu" last="Yang">Rui Fu Yang</name><name sortKey="Yang, Sheng" sort="Yang, Sheng" uniqKey="Yang S" first="Sheng" last="Yang">Sheng Yang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Lu, Wei" sort="Lu, Wei" uniqKey="Lu W" first="Wei" last="Lu">Wei Lu</name></noRegion><name sortKey="Bian, Chao" sort="Bian, Chao" uniqKey="Bian C" first="Chao" last="Bian">Chao Bian</name><name sortKey="Ji, Yong Yong" sort="Ji, Yong Yong" uniqKey="Ji Y" first="Yong Yong" last="Ji">Yong Yong Ji</name><name sortKey="Lin, Guo Mei" sort="Lin, Guo Mei" uniqKey="Lin G" first="Guo-Mei" last="Lin">Guo-Mei Lin</name><name sortKey="Lin, Ying" sort="Lin, Ying" uniqKey="Lin Y" first="Ying" last="Lin">Ying Lin</name><name sortKey="Pei, Gang" sort="Pei, Gang" uniqKey="Pei G" first="Gang" last="Pei">Gang Pei</name><name sortKey="Shi, Mu De" sort="Shi, Mu De" uniqKey="Shi M" first="Mu De" last="Shi">Mu De Shi</name><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><name sortKey="Tian, Lin" sort="Tian, Lin" uniqKey="Tian L" first="Lin" last="Tian">Lin Tian</name><name sortKey="Wu, Jia Rui" sort="Wu, Jia Rui" uniqKey="Wu J" first="Jia Rui" last="Wu">Jia Rui Wu</name><name sortKey="Wu, Xiao Dong" sort="Wu, Xiao Dong" uniqKey="Wu X" first="Xiao-Dong" last="Wu">Xiao-Dong Wu</name><name sortKey="Xie, You Hua" sort="Xie, You Hua" uniqKey="Xie Y" first="You Hua" last="Xie">You Hua Xie</name><name sortKey="Yan, Lin Chen" sort="Yan, Lin Chen" uniqKey="Yan L" first="Lin-Chen" last="Yan">Lin-Chen Yan</name><name sortKey="Zhu, Xue Liang" sort="Zhu, Xue Liang" uniqKey="Zhu X" first="Xue-Liang" last="Zhu">Xue-Liang Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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